Foslevodopa
(2S)-2-amino-3-(3-hydroxy-4-phosphonooxyphenyl)propanoic acid
Molecular Identity
Foslevodopa
(2S)-2-amino-3-(3-hydroxy-4-phosphonooxyphenyl)propanoic acid
PubChem CID: 127766
Foslevodopa is an L-tyrosine derivative that is L-dopa in which the hydroxy group at position 4' is replaced by a phosphonooxy group. It is a water-soluble prodrug of levodopa which is used for the treatment of Parkinson's disease. It has a role as an antiparkinson drug and a prodrug. It is an O-phosphoamino acid, a L-tyrosine derivative and a non-proteinogenic L-alpha-amino acid. It is functionally related to a L-dopa.
2D Structure
Properties
C9H12NO7P
Molecular Formula
277.17
Molecular Weight
g/mol
277.0351
Exact Mass
Da
-4
XLogP
Drug-like (Lipinski: < 5)
150
TPSA
May have limited oral absorption
5
H-Bond Donors
8
H-Bond Acceptors
344
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
Foslevodopa97321-87-4Levodopa-4'-monophosphate3-hydroxy-O-phosphono-L-tyrosineFoslevodopa [USAN](2S)-2-amino-3-(3-hydroxy-4-phosphonooxyphenyl)propanoic acid37NQZ0J76IFOSLEVODOPA [INN]FOSLEVODOPA [JAN]ABBV-951 COMPONENT FOSLEVODOPAL-TYROSINE, 3-HYDROXY-O-PHOSPHONO-L-TYROSINE, 3-HYDROXY-, 4-(DIHYDROGEN PHOSPHATE)foslevodopumRefChem:600352Dopa 4-phosphate
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Foslevodopa
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