Linifanib
1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methylphenyl)urea
Molecular Identity
Linifanib
1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methylphenyl)urea
PubChem CID: 11485656
Linifanib is a member of the class of phenylureas that is urea in which one of the nitrogens is substituted by a 2-fluoro-5-methylphenyl group, while the other is substituted by a p-(3-amino-1H-indazol-4-yl)phenyl group. It is a potent, selective inhibitor of vascular endothelial growth factor and platelet-derived growth factor receptor tyrosine kinases. It has a role as an antineoplastic agent, an angiogenesis inhibitor and an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor. It is a member of phenylureas, an aromatic amine and a member of indazoles.
2D Structure
Properties
C21H18FN5O
Molecular Formula
375.40
Molecular Weight
g/mol
375.1495
Exact Mass
Da
3.9
XLogP
Drug-like (Lipinski: < 5)
95.8
TPSA
Good oral absorption (< 140 A²)
4
H-Bond Donors
4
H-Bond Acceptors
541
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
Linifanib796967-16-3ABT-8691-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(2-fluoro-5-methylphenyl)ureaABT 869AL-39324N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)ureaABT8691-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methylphenyl)urealinifanibumRG-3635CO93X137CWRG3635CHEBI:91435DTXSID40229834
Data from PubChem (NCBI)
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Trials and conditions connected to Linifanib
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