Afatinib Dimaleate
bis((Z)-but-2-enedioic acid);(E)-N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide
Molecular Identity
Afatinib Dimaleate
bis((Z)-but-2-enedioic acid);(E)-N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide
PubChem CID: 15606394
Afatinib dimaleate is a maleate salt obtained by combining afatinib with two molar equivalents of maleic acid. Used for the first-line treatment of patients with metastatic non-small cell lung cancer. It has a role as an antineoplastic agent and a tyrosine kinase inhibitor. It contains an afatinib.
2D Structure
Properties
C32H33ClFN5O11
Molecular Formula
718.10
Molecular Weight
g/mol
717.1849
Exact Mass
Da
238
TPSA
May have limited oral absorption
6
H-Bond Donors
16
H-Bond Acceptors
820
Complexity
SMILES
Canonical SMILES
SMILES: CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4.C(=CC(=O)O)C(=O)O.C(=CC(=O)O)C(=O)OIsomeric SMILES
SMILES: CN(C/C=C/C(=O)NC1=C(C=C2N=CN=C(C2=C1)NC3=CC(=C(C=C3)F)Cl)O[C@@H]4COCC4)C.C(=C\C(=O)O)\C(=O)O.C(=C\C(=O)O)\C(=O)OSynonyms(20)
AFATINIB DIMALEATE850140-73-7GilotrifAfatinib maleateGiotrifBIBW 2992MA2BIBW2992 MA2BIBW2992-MA2V1T5K7RZ0BBIBW-2992MA2BIBW-2992 MA2BIBW-2992-MA2CHEBI:76003DTXSID701027713RefChem:56996
Data from PubChem (NCBI)
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Drug Network
Trials and conditions connected to Afatinib Dimaleate
Loading drug network...