Eltrombopag
3-[3-[[2-(3,4-dimethylphenyl)-5-methyl-3-oxo-1H-pyrazol-4-yl]diazenyl]-2-hydroxyphenyl]benzoic acid
Molecular Identity
Eltrombopag
3-[3-[[2-(3,4-dimethylphenyl)-5-methyl-3-oxo-1H-pyrazol-4-yl]diazenyl]-2-hydroxyphenyl]benzoic acid
PubChem CID: 135449332
Eltrombopag is a hydrazine in which each nitrogen atom is substituted, one by a 3'-carboxy-2-hydroxy[1,1'-biphenyl]-3-yl group and the other by a 1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene group. A small molecule agonist of the c-mpl (TpoR) receptor (the physiological target of the hormone thrombopoietin), it has been developed as a medication for conditions that lead to thrombocytopenia (abnormally low platelet counts). It has a role as a xenobiotic and a thrombopoietin receptor agonist. It is a member of benzoic acids, a member of hydrazines and a member of pyrazoles.
2D Structure
Properties
C25H22N4O4
Molecular Formula
442.50
Molecular Weight
g/mol
442.1641
Exact Mass
Da
5.4
XLogP
Above Lipinski threshold
115
TPSA
Good oral absorption (< 140 A²)
3
H-Bond Donors
7
H-Bond Acceptors
812
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
Eltrombopag496775-61-2(Z)-3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acidEltrombopag [INN]SB497115SB 497115(E)-Eltrombopag376591-99-0UNII-S56D65XJ9G(ZE)-EltrombopagMFCD20926253Eltrombopag free baseSB-4971151807882-48-93'-[2-[(2Z)-1-(3,4-Dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazinyl]-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Eltrombopag
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