Tizaterkib
(6R)-7-[(3,4-difluorophenyl)methyl]-6-(methoxymethyl)-2-[5-methyl-2-[(2-methylpyrazol-3-yl)amino]pyrimidin-4-yl]-5,6-dihydroimidazo[1,2-a]pyrazin-8-one
Molecular Identity
Tizaterkib
(6R)-7-[(3,4-difluorophenyl)methyl]-6-(methoxymethyl)-2-[5-methyl-2-[(2-methylpyrazol-3-yl)amino]pyrimidin-4-yl]-5,6-dihydroimidazo[1,2-a]pyrazin-8-one
PubChem CID: 129116690
2D Structure
Properties
C24H24F2N8O2
Molecular Formula
494.50
Molecular Weight
g/mol
494.1990
Exact Mass
Da
2
XLogP
Drug-like (Lipinski: < 5)
103
TPSA
Good oral absorption (< 140 A²)
1
H-Bond Donors
9
H-Bond Acceptors
768
Complexity
SMILES
Canonical SMILES
SMILES: CC1=CN=C(N=C1C2=CN3CC(N(C(=O)C3=N2)CC4=CC(=C(C=C4)F)F)COC)NC5=CC=NN5CIsomeric SMILES
SMILES: CC1=CN=C(N=C1C2=CN3C[C@@H](N(C(=O)C3=N2)CC4=CC(=C(C=C4)F)F)COC)NC5=CC=NN5CSynonyms(20)
2097416-76-5AZD0364tizaterkibAZD-0364ATG-017VO9KX45QIQ(6R)-7-[(3,4-difluorophenyl)methyl]-6-(methoxymethyl)-2-[5-methyl-2-[(2-methylpyrazol-3-yl)amino]pyrimidin-4-yl]-5,6-dihydroimidazo[1,2-a]pyrazin-8-oneATG017AZD 0364(R)-7-(3,4-difluorobenzyl)-6-(methoxymethyl)-2-(5-methyl-2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)-6,7-dihydroimidazo[1,2-a]pyrazin-8(5H)-oneAZ13820216AZ-13820216(R)-7-(3,4-Difluorobenzyl)-6-(methoxymethyl)-2-(5-methyl-2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)-6,7-dihydroimidazo(1,2-a)pyrazin-8(5H)-one(6R)-7-((3,4-difluorophenyl)methyl)-6-(methoxymethyl)-2-(5-methyl-2-((2-methylpyrazol-3-yl)amino)pyrimidin-4-yl)-5,6-dihydroimidazo(1,2-a)pyrazin-8-one(R)-7-(3,4-Difluorobenzyl)-6-(methoxymethyl)-2-{5-methyl-2-[(1-methyl-1H-pyrazol-5-yl)amino]pyrimidin-4-yl}-6,7-dihydroimidazo[1,2-a]pyrazin-8(5H)-one
Data from PubChem (NCBI)
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