Azd-0424
1-[4-[2-[4-[(6-chloro-[1,3]dioxolo[4,5-b]pyridin-7-yl)amino]-5-propan-2-yloxyquinazolin-7-yl]oxyethyl]piperazin-1-yl]ethanone
Molecular Identity
Azd-0424
1-[4-[2-[4-[(6-chloro-[1,3]dioxolo[4,5-b]pyridin-7-yl)amino]-5-propan-2-yloxyquinazolin-7-yl]oxyethyl]piperazin-1-yl]ethanone
PubChem CID: 9893171
2D Structure
Properties
C25H29ClN6O5
Molecular Formula
529.00
Molecular Weight
g/mol
528.1888
Exact Mass
Da
3.2
XLogP
Drug-like (Lipinski: < 5)
111
TPSA
Good oral absorption (< 140 A²)
1
H-Bond Donors
10
H-Bond Acceptors
759
Complexity
SMILES
Canonical SMILES
SMILES: CC(C)OC1=CC(=CC2=C1C(=NC=N2)NC3=C4C(=NC=C3Cl)OCO4)OCCN5CCN(CC5)C(=O)CIsomeric SMILES
SMILES: CC(C)OC1=CC(=CC2=C1C(=NC=N2)NC3=C4C(=NC=C3Cl)OCO4)OCCN5CCN(CC5)C(=O)CSynonyms(20)
AZD0424AZD-0424692054-06-1Piperazine, 1-acetyl-4-(2-((4-((6-chloro-1,3-dioxolo(4,5-b)pyridin-7-yl)amino)-5-(1-methylethoxy)-7-quinazolinyl)oxy)ethyl)-642PS513247-(2-(4-Acetylpiperazin-1-yl)ethoxy)-4-(5-chloro-2,3-methylenedioxypyridin-4-ylamino)-5-isopropoxyquinazolineEthanone, 1-(4-(2-((4-((6-chloro-1,3-dioxolo(4,5-b)pyridin-7-yl)amino)-5-(1-methylethoxy)-7-quinazolinyl)oxy)ethyl)-1-piperazinyl)-1-(4-(2-((4-((6-Chloro(1,3)dioxolo(4,5-b)pyridin-7-yl)amino)-5-isopropoxy-7-quinazolinyl)oxy)ethyl)-1-piperazinyl)ethanoneRefChem:115983Src/Abl Kinase Inhibitor AZD04241-(4-(2-((4-((6-chloro-2H-(1,3)dioxolo(4,5-b)pyridin-7-yl)amino)-5-(propan-2-yloxy)quinazolin-7-yl)oxy)ethyl)piperazin-1-yl)ethan-1-oneUNII-642PS513241-[4-[2-[4-[(6-chloro-[1,3]dioxolo[4,5-b]pyridin-7-yl)amino]-5-propan-2-yloxyquinazolin-7-yl]oxyethyl]piperazin-1-yl]ethanoneMVWATCATLSSVBH-UHFFFAOYSA-Norb1707615
Data from PubChem (NCBI)
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