Barasertib
2-[ethyl-[3-[4-[[5-[2-(3-fluoroanilino)-2-oxoethyl]-1H-pyrazol-3-yl]amino]quinazolin-7-yl]oxypropyl]amino]ethyl dihydrogen phosphate
Molecular Identity
Barasertib
2-[ethyl-[3-[4-[[5-[2-(3-fluoroanilino)-2-oxoethyl]-1H-pyrazol-3-yl]amino]quinazolin-7-yl]oxypropyl]amino]ethyl dihydrogen phosphate
PubChem CID: 11497983
AZT-1152 is a dihydrogen phosphate prodrug of a pyrazoloquinazoline aurora kinase inhibitor AZD1152-hydroxyquinazoline pyrazol anilide(HQPA) and is converted rapidly to the active AZD1152-HQPA in plasma. It has a role as an antineoplastic agent, a prodrug and an Aurora kinase inhibitor. It is an anilide, a secondary carboxamide, a monoalkyl phosphate, a member of pyrazoles, a member of quinazolines, a secondary amino compound, a tertiary amino compound and a member of monofluorobenzenes. It is functionally related to an AZD-1152.
2D Structure
Properties
C26H31FN7O6P
Molecular Formula
587.50
Molecular Weight
g/mol
587.2057
Exact Mass
Da
-0.4
XLogP
Drug-like (Lipinski: < 5)
175
TPSA
May have limited oral absorption
5
H-Bond Donors
12
H-Bond Acceptors
859
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
Barasertib722543-31-9barasertibum16XC2U7W8NDTXSID002225832-[ethyl-[3-[4-[[5-[2-(3-fluoroanilino)-2-oxoethyl]-1H-pyrazol-3-yl]amino]quinazolin-7-yl]oxypropyl]amino]ethyl dihydrogen phosphate1H-PYRAZOLE-3-ACETAMIDE, 5-((7-(3-(ETHYL(2-(PHOSPHONOOXY)ETHYL)AMINO)PROPOXY)-4-QUINAZOLINYL)AMINO)-N-(3-FLUOROPHENYL)-2-(ethyl-(3-(4-((5-(2-(3-fluoroanilino)-2-oxoethyl)-1H-pyrazol-3-yl)amino)quinazolin-7-yl)oxypropyl)amino)ethyl dihydrogen phosphateRefChem:916707DTXCID30145074Aurora Kinase Inhibitor AZD1152(2-(ethyl(3-((4-((3-(((3-fluorophenyl)carbamoyl)methyl)-1H-pyrazol-5-yl)amino)quinazolin-7-yl)oxy)propyl)amino)ethoxy)phosphonic acidAZD1152957881-03-7AZD-1152
Data from PubChem (NCBI)
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Drug Network
Trials and conditions connected to Barasertib
Loading drug network...