Azd8055
[5-[2,4-bis[(3S)-3-methylmorpholin-4-yl]pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol
Molecular Identity
Azd8055
[5-[2,4-bis[(3S)-3-methylmorpholin-4-yl]pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol
PubChem CID: 25262965
AZD-8055 is a pyridopyrimidine that is pyrido[2,3-d]pyrimidine which is substituted at positions 2 and 4 by (3S)-3-methylmorpholin-4-yl groups and at position 5 by a 3-(hydroxymethyl)-4-methoxyphenyl group. It is an mTOR complex 1/2 (mTORC1/2) dual inhibitor [mTOR = mammalian target of rapamycin]. It has a role as an antineoplastic agent, a mTOR inhibitor and an apoptosis inducer. It is a member of benzyl alcohols, a member of morpholines, a pyridopyrimidine and a tertiary amino compound.
2D Structure
Properties
C25H31N5O4
Molecular Formula
465.50
Molecular Weight
g/mol
465.2376
Exact Mass
Da
2.6
XLogP
Drug-like (Lipinski: < 5)
93.1
TPSA
Good oral absorption (< 140 A²)
1
H-Bond Donors
9
H-Bond Acceptors
659
Complexity
SMILES
Canonical SMILES
SMILES: CC1COCCN1C2=NC(=NC3=C2C=CC(=N3)C4=CC(=C(C=C4)OC)CO)N5CCOCC5CIsomeric SMILES
SMILES: C[C@H]1COCCN1C2=NC(=NC3=C2C=CC(=N3)C4=CC(=C(C=C4)OC)CO)N5CCOC[C@@H]5CSynonyms(20)
AZD8055AZD 8055DTXSID001020704RefChem:560465DTXCID001493218MTOR KINASE INHIBITOR AZD80551009298-09-2AZD-8055(5-(2,4-bis((S)-3-methylmorpholino)pyrido[2,3-d]pyrimidin-7-yl)-2-methoxyphenyl)methanol[5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanolUNII-970JJ37FPW970JJ37FPW(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanolBenzenemethanol, 5-[2,4-bis[(3S)-3-methyl-4-morpholinyl]pyrido[2,3-d]pyrimidin-7-yl]-2-methoxy-MFCD16660191
Data from PubChem (NCBI)
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Drug Network
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