Riociguat
methyl N-[4,6-diamino-2-[1-[(2-fluorophenyl)methyl]pyrazolo[5,4-b]pyridin-3-yl]pyrimidin-5-yl]-N-methylcarbamate
Molecular Identity
Riociguat
methyl N-[4,6-diamino-2-[1-[(2-fluorophenyl)methyl]pyrazolo[5,4-b]pyridin-3-yl]pyrimidin-5-yl]-N-methylcarbamate
PubChem CID: 11304743
Riociguat is a carbamate ester that is the methyl ester of {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}methylcarbamic acid. It is used for treatment of chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension. It has a role as an antihypertensive agent and a soluble guanylate cyclase activator. It is a carbamate ester, an organofluorine compound, an aminopyrimidine and a pyrazolopyridine.
2D Structure
Properties
C20H19FN8O2
Molecular Formula
422.40
Molecular Weight
g/mol
422.1615
Exact Mass
Da
1.6
XLogP
Drug-like (Lipinski: < 5)
138
TPSA
Good oral absorption (< 140 A²)
2
H-Bond Donors
9
H-Bond Acceptors
618
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
Riociguat625115-55-1AdempasBAY 63-2521BAY-63-2521riociguatumRU3FE2Y4XImethyl N-(4,6-diamino-2-{1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl}pyrimidin-5-yl)-N-methylcarbamateCHEBI:76018DTXSID50978109Methyl N-(4,6-diamino-2-{1-((2-fluorophenyl)methyl)-1H-pyrazolo(3,4-b)pyridin-3-yl}pyrimidin-5-yl)-N-methylcarbamateMETHYL N-(4,6-DIAMINO-2-(1-((2-FLUOROPHENYL)METHYL)-1H-PYRAZOLO(3,4-B)PYRIDIN-3-YL)PYRIMIDIN-5-YL)-N-METHYLCARBAMATERefChem:59037C02KX05DTXCID901405436
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Riociguat
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