Flavopiridol hydrochloride
2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]chromen-4-one;hydrochloride
Molecular Identity
Flavopiridol hydrochloride
2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]chromen-4-one;hydrochloride
PubChem CID: 9910986
Alvocidib hydrochloride is a hydrochloride salt resulting from the formal reaction of equimolar amounts of alvocidib and hydrogen chloride. A cyclin-dependent kinase 9 (CDK9) inhibitor, it has been studied for the treatment of acute myeloid leukaemia, arthritis and atherosclerotic plaque formation. It has a role as an antineoplastic agent, an antirheumatic drug, an apoptosis inducer and an EC 2.7.11.22 (cyclin-dependent kinase) inhibitor. It contains an alvocidib(1+).
2D Structure
Properties
C21H21Cl2NO5
Molecular Formula
438.30
Molecular Weight
g/mol
437.0797
Exact Mass
Da
90.2
TPSA
Good oral absorption (< 140 A²)
4
H-Bond Donors
6
H-Bond Acceptors
628
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
Flavopiridol hydrochloride131740-09-5Alvocidib hydrochlorideFlavopiridol HClHL 275HMR 1275Alvocidib hydrochloride [USAN]HL-275MFCD267925542-(2-chlorophenyl)-5,7-dihydroxy-8-((3S,4R)-3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-one hydrochlorideL 86 8275D48MS3A6N9HMR-1275MDL-107826ADTXSID6048961
Data from PubChem (NCBI)
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