Molecular Identity
Amorolfine
(2S,6R)-2,6-dimethyl-4-[2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl]morpholine
PubChem CID: 54260
Amorolfine is a member of the class of morpholines that is cis-2,6-dimethylmorpholine in which the hydrogen attached to the nitrogen is replaced by a racemic 2-methyl-3-[p-(2-methylbutan-2-yl)phenyl]propyl group. An inhibitor of the action of squalene monooxygenase, 14 reductase and D7-D8 isomerase and an antifungal agent, it is used (generally as its hydrochloride salt) for the topical treatment of fungal nail and skin infections. It has a role as an EC 1.14.13.132 (squalene monooxygenase) inhibitor, an EC 1.3.1.70 (Delta(14)-sterol reductase) inhibitor and an EC 5.3.3.5 (cholestenol Delta-isomerase) inhibitor. It is a tertiary amino compound and a morpholine antifungal drug. It is a conjugate base of an amorolfine(1+).
2D Structure
Properties
C21H35NO
Molecular Formula
317.50
Molecular Weight
g/mol
317.2719
Exact Mass
Da
5.7
XLogP
Above Lipinski threshold
12.5
TPSA
Good oral absorption (< 140 A²)
0
H-Bond Donors
2
H-Bond Acceptors
336
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
Amorolfine78613-35-1LocerylAmorolfinaAmorolfinumamorolfinCuranailLocetarOdenilDTXSID0046690Amorolfine (as hydrochloride)(2R,6S)-2,6-dimethyl-4-{2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl}morpholineDTXCID8026690CHEBI:599440Ro 14-4767/000
Data from PubChem (NCBI)
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Drug Network
Trials and conditions connected to Amorolfine
Loading drug network...