Molecular Identity
Apraclonidine
2,6-dichloro-1-N-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine
PubChem CID: 2216
Apraclonidine is an imidazoline that is 2-amino 4,5-dihydro-1H-imidazoline in which one of the exocyclic amino hydrogens has been replaced by a 4-amino-2,6-dichlorophenyl group. It has a role as a diagnostic agent, a beta-adrenergic agonist, an alpha-adrenergic agonist, an antiglaucoma drug and an ophthalmology drug. It is a dichlorobenzene, a member of guanidines and a member of imidazolines. It is a conjugate base of an apraclonidine(1+).
2D Structure
Properties
C9H10Cl2N4
Molecular Formula
245.11
Molecular Weight
g/mol
244.0283
Exact Mass
Da
1.3
XLogP
Drug-like (Lipinski: < 5)
62.4
TPSA
Good oral absorption (< 140 A²)
3
H-Bond Donors
2
H-Bond Acceptors
246
Complexity
SMILES
Canonical SMILES
SMILES: C1CN=C(N1)NC2=C(C=C(C=C2Cl)N)ClIsomeric SMILES
SMILES: C1CN=C(N1)NC2=C(C=C(C=C2Cl)N)ClSynonyms(20)
apraclonidine66711-21-54-AminoclonidineApraclonidinaApraclonidinump-aminoclonidine2,6-dichloro-1-N-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine843CEN85DICHEBI:2788DTXSID10484151,4-Benzenediamine, 2,6-dichloro-N'-(4,5-dihydro-1H-imidazol-2-yl)-para-aminoclonidineIopimax2-(4-amino-2,6-dichloro)phenyliminoimidazolidineRefChem:57693
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Apraclonidine
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