Armodafinil
2-[(R)-benzhydrylsulfinyl]acetamide
Molecular Identity
Armodafinil
2-[(R)-benzhydrylsulfinyl]acetamide
PubChem CID: 9690109
Armodafinil is a 2-[(diphenylmethyl)sulfinyl]acetamide that has R configuration at the sulfur atom. Like its racemate, modafinil, it is used for the treatment of sleeping disorders such as narcolepsy, obstructive sleep apnoea, and shift-work sleep disorder. Peak concentration in the blood later occurs later following administration than with modafinil, so it is thought that armodafinil may be more effective than modafinil in treating people with excessive daytime sleepiness. It has a role as a central nervous system stimulant and a eugeroic. It is an enantiomer of a (S)-modafinil.
2D Structure
Properties
C15H15NO2S
Molecular Formula
273.40
Molecular Weight
g/mol
273.0823
Exact Mass
Da
1.7
XLogP
Drug-like (Lipinski: < 5)
79.4
TPSA
Good oral absorption (< 140 A²)
1
H-Bond Donors
3
H-Bond Acceptors
302
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
Armodafinil112111-43-0Nuvigil(R)-Modafinil(-)-Modafinil(R)-(-)-ModafinilCEP-10953armodafiniloModafinil, (r)-R-(-)-Modafinil2-[(R)-(Diphenylmethyl)sulfinyl]acetamidearmodafinilum(-)-(R)-modafinilCEP 10953CEP-10952
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Armodafinil
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