Silevertinib
(E)-N-[4-(3-chloro-2-fluoroanilino)-7-[2-[(1R,5S)-3-methyl-3-azabicyclo[3.1.0]hexan-1-yl]ethynyl]quinazolin-6-yl]-4-morpholin-4-ylbut-2-enamide
Molecular Identity
Silevertinib
(E)-N-[4-(3-chloro-2-fluoroanilino)-7-[2-[(1R,5S)-3-methyl-3-azabicyclo[3.1.0]hexan-1-yl]ethynyl]quinazolin-6-yl]-4-morpholin-4-ylbut-2-enamide
PubChem CID: 156071569
2D Structure
Properties
C30H30ClFN6O2
Molecular Formula
561.00
Molecular Weight
g/mol
560.2103
Exact Mass
Da
3.9
XLogP
Drug-like (Lipinski: < 5)
82.6
TPSA
Good oral absorption (< 140 A²)
2
H-Bond Donors
8
H-Bond Acceptors
1010
Complexity
SMILES
Canonical SMILES
SMILES: CN1CC2CC2(C1)C#CC3=CC4=C(C=C3NC(=O)C=CCN5CCOCC5)C(=NC=N4)NC6=C(C(=CC=C6)Cl)FIsomeric SMILES
SMILES: CN1C[C@H]2C[C@]2(C1)C#CC3=CC4=C(C=C3NC(=O)/C=C/CN5CCOCC5)C(=NC=N4)NC6=C(C(=CC=C6)Cl)FSynonyms(20)
BDTX-15352607829-38-7SilevertinibRP9F537KVYRefChem:1098520EGFR-IN-76(E)-N-(4-((3-Chloro-2-fluorophenyl)amino)-7-(((1R,5S)-3-methyl-3-azabicyclo[3.1.0]hexan-1-yl)ethynyl)quinazolin-6-yl)-4-morpholinobut-2-enamide(E)-N-[4-(3-chloro-2-fluoroanilino)-7-[2-[(1R,5S)-3-methyl-3-azabicyclo[3.1.0]hexan-1-yl]ethynyl]quinazolin-6-yl]-4-morpholin-4-ylbut-2-enamidesilevertinib [INN]Silevertinib (USAN/INN)SILEVERTINIB [USAN]BDTX1535orb1982304orb2900531SCHEMBL22983932
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Silevertinib
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