667463-62-9
6-bromo-3-(3-nitroso-1H-indol-2-yl)-1H-indol-2-ol
Molecular Identity
667463-62-9
6-bromo-3-(3-nitroso-1H-indol-2-yl)-1H-indol-2-ol
PubChem CID: 448949
6-bromoindirubin-3'-oxime is a member of the class of biindoles that is indirubin substituted at position 6 by a bromo group and in which the keto group at position 3' has undergone condensation with hydroxylamine to form the corresponding oxime. It has a role as an EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor and an EC 2.7.11.26 (tau-protein kinase) inhibitor. It is a ketoxime, an organobromine compound, a member of oxindoles and a biindole.
2D Structure
Properties
C16H10BrN3O2
Molecular Formula
356.17
Molecular Weight
g/mol
354.9956
Exact Mass
Da
3.9
XLogP
Drug-like (Lipinski: < 5)
81.2
TPSA
Good oral absorption (< 140 A²)
3
H-Bond Donors
3
H-Bond Acceptors
438
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
667463-62-9BIO6-BROMOINDIRUBIN-3'-OXIMEGSK-3 Inhibitor IXGSK 3 Inhibitor IX6BIO6-bromoindirubin-3-oxime(2'Z,3'E)-6-Bromoindirubin-3'-oxime6-BIOGSK 3B Inhibitor IX(2Z,3E)-6-Bromoindirubin-3'-oxime6BIO cpd(2Z,3E)-6'-Bromo-3-(hydroxyimino)-[2,3'-biindolinylidene]-2'-oneGSK 3 IXC16H10BrN3O2
Data from PubChem (NCBI)
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