Leniolisib phosphate
1-[(3S)-3-[[6-[6-methoxy-5-(trifluoromethyl)-3-pyridinyl]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]amino]pyrrolidin-1-yl]propan-1-one;phosphoric acid
Molecular Identity
Leniolisib phosphate
1-[(3S)-3-[[6-[6-methoxy-5-(trifluoromethyl)-3-pyridinyl]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]amino]pyrrolidin-1-yl]propan-1-one;phosphoric acid
PubChem CID: 90214495
Leniolisib phosphate is a phosphate salt obtained by reaction leniolisib with one equivalent of phosphoric acid. It is used to treat activated phosphoinositide 3-kinase delta (PI3Kdelta) syndrome in adults and children 12 years of age and older. It has a role as an EC 2.7.1.153 (phosphatidylinositol-4,5-bisphosphate 3-kinase) inhibitor and an immunomodulator. It contains a leniolisib.
2D Structure
Properties
C21H28F3N6O6P
Molecular Formula
548.50
Molecular Weight
g/mol
548.1760
Exact Mass
Da
161
TPSA
May have limited oral absorption
4
H-Bond Donors
14
H-Bond Acceptors
703
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
Leniolisib phosphate1354691-97-6Leniolisib monophosphateJOENJACDZ173-AZ3700M1H39QCDZ-173-AZCDZ-1731-Propanone, 1-((3S)-3-((5,6,7,8-tetrahydro-6-(6-methoxy-5-(trifluoromethyl)-3-pyridinyl)pyrido(4,3-d)pyrimidin-4-yl)amino)-1-pyrrolidinyl)-, phosphate (1:1)RefChem:57739Cdz173Leniolisib (phosphate)UNII-3700M1H39Q1-[(3S)-3-[[6-[6-methoxy-5-(trifluoromethyl)pyridin-3-yl]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]amino]pyrrolidin-1-yl]propan-1-one;phosphoric acidJoenja (TN)
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Leniolisib phosphate
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