CT-179
1-(3,4-dichlorophenyl)-3-[4-[3-(dimethylamino)propylamino]-6-methylpyrimidin-2-yl]urea
Molecular Identity
CT-179
1-(3,4-dichlorophenyl)-3-[4-[3-(dimethylamino)propylamino]-6-methylpyrimidin-2-yl]urea
PubChem CID: 122520266
CT-179 is a member of the class of pyridines that is pyridine substituted by [(3,4-dichlorophenyl)carbamoyl]amino, [3-(dimethylamino)propyl]amino, and methyl groups at positions 2, 4 and 6, respectively. It is a small molecule inhibitor of OLIG2 developed by Curtana Pharmaceuticals for the treatment of glioblastoma, medulloblastoma, and other brain cancers. It has a role as an OLIG2 inhibitor and an antineoplastic agent. It is a member of phenylureas, a dichlorobenzene, a member of pyridines, a secondary amino compound and a tertiary amino compound.
2D Structure
Properties
C17H22Cl2N6O
Molecular Formula
397.30
Molecular Weight
g/mol
396.1232
Exact Mass
Da
3.5
XLogP
Drug-like (Lipinski: < 5)
82.2
TPSA
Good oral absorption (< 140 A²)
3
H-Bond Donors
5
H-Bond Acceptors
441
Complexity
SMILES
Canonical SMILES
SMILES: CC1=CC(=NC(=N1)NC(=O)NC2=CC(=C(C=C2)Cl)Cl)NCCCN(C)CIsomeric SMILES
SMILES: CC1=CC(=NC(=N1)NC(=O)NC2=CC(=C(C=C2)Cl)Cl)NCCCN(C)CSynonyms(20)
CT-1791996636-69-14Z0F3ZM8ZDCT179UNII-4Z0F3ZM8ZD1-(2-(3-(3,4-Dichlorophenyl)ureido)-6-methyl-pyrimidin-4-yl)-amino-3(dimethylamino)propaneCT 179Urea, N-(3,4-dichlorophenyl)-N'-(4-((3-(dimethylamino)propyl)amino)-6-methyl-2-pyrimidinyl)-RefChem:1286871-(3,4-Dichlorophenyl)-3-(4-((3-(dimethylamino)propyl)amino)-6-methylpyrimidin-2-yl)urea1-(3,4-dichlorophenyl)-3-(4-{[3-(dimethylamino)propyl]amino}-6-methylpyrimidin-2-yl)ureaorb1739473SCHEMBL18053805SCHEMBL29349616SCHEMBL29486340
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to CT-179
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