Cabozantinib
1-N-[4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-1-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
Molecular Identity
Cabozantinib
1-N-[4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-1-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
PubChem CID: 25102847
Cabozantinib is a dicarboxylic acid diamide that is N-phenyl-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide in which the hydrogen at position 4 on the phenyl ring is substituted by a (6,7-dimethoxyquinolin-4-yl)oxy group. A multi-tyrosine kinase inhibitor, used (as its malate salt) for the treatment of progressive, metastatic, medullary thyroid cancer. It has a role as an antineoplastic agent and a tyrosine kinase inhibitor. It is a member of quinolines, an aromatic ether, a dicarboxylic acid diamide and an organofluorine compound.
2D Structure
Properties
C28H24FN3O5
Molecular Formula
501.50
Molecular Weight
g/mol
501.1700
Exact Mass
Da
5.4
XLogP
Above Lipinski threshold
98.8
TPSA
Good oral absorption (< 140 A²)
2
H-Bond Donors
7
H-Bond Acceptors
795
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
Cabozantinib849217-68-1XL 184XL-184XL-184 free baseBMS-907351BMS 907351N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamideCHEBI:723171C39JW444GBMS-907351 FREE BASEXL184 cpdBMS907351DTXSID102339681,1-Cyclopropanedicarboxamide, N'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N-(4-fluorophenyl)-
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Cabozantinib
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