Carglumic acid
(2S)-2-(carbamoylamino)pentanedioic acid
Molecular Identity
Carglumic acid
(2S)-2-(carbamoylamino)pentanedioic acid
PubChem CID: 121396
Carglumic acid is a urea that is the N-carbamoyl derivative of L-glutamic acid. An orphan drug used to treat a deficiency in the enzyme N-acetylglutamate synthase, which leads to acute hyperammonaemia. It has a role as an orphan drug and a carbamylphosphate synthetase I activator. It is a N-acyl-L-glutamic acid and a member of ureas. It is a conjugate acid of a N-carbamoyl-L-glutamate(2-).
2D Structure
Properties
C6H10N2O5
Molecular Formula
190.15
Molecular Weight
g/mol
190.0590
Exact Mass
Da
-2.4
XLogP
Drug-like (Lipinski: < 5)
130
TPSA
Good oral absorption (< 140 A²)
4
H-Bond Donors
5
H-Bond Acceptors
227
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
Carglumic acid1188-38-1N-Carbamyl-L-glutamic acidCarbagluN-Carbamoyl-L-glutamic acid(2S)-2-(carbamoylamino)pentanedioic acidUreidoglutaric acidCarbamylglutamic acidCarbamino-L-glutamic acidL-N-Carbamoylglutamic acidacido carglumicoacide carglumiqueL-Glutamic acid, N-(aminocarbonyl)-acidum carglumicum5L0HB4V1EW
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Carglumic acid
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