Molecular Identity
Carbidopa
(2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid
PubChem CID: 34359
Carbidopa (anhydrous) is 3-(3,4-Dihydroxyphenyl)propanoic acid in which the hydrogens alpha- to the carboxyl group are substituted by hydrazinyl and methyl groups (S-configuration). Carbidopa is a dopa decarboxylase inhibitor, so prevents conversion of levodopa to dopamine. It has no antiparkinson activity by itself, but is used (commonly as its hydrate) in the management of Parkinson's disease to reduce peripheral adverse effects of levodopa. It has a role as an antiparkinson drug, a dopaminergic agent and an EC 4.1.1.28 (aromatic-L-amino-acid decarboxylase) inhibitor. It is a member of hydrazines, a monocarboxylic acid and a member of catechols.
2D Structure
Properties
C10H14N2O4
Molecular Formula
226.23
Molecular Weight
g/mol
226.0954
Exact Mass
Da
-2.2
XLogP
Drug-like (Lipinski: < 5)
116
TPSA
Good oral absorption (< 140 A²)
5
H-Bond Donors
6
H-Bond Acceptors
261
Complexity
SMILES
Canonical SMILES
SMILES: CC(CC1=CC(=C(C=C1)O)O)(C(=O)O)NNIsomeric SMILES
SMILES: C[C@](CC1=CC(=C(C=C1)O)O)(C(=O)O)NNSynonyms(20)
carbidopa28860-95-9LodosynCarbidopa anhydrous(S)-carbidopa(S)-(-)-carbidopaN-Aminomethyldopaalpha-MethyldopahydrazineCarbidopumL-alpha-MethyldopahydrazineCarbidopa (anhydrous)(2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acidMK 486L-3-(3,4-Dihydroxyphenyl)-2-methyl-2-hydrazinopropionic acidDTXSID4022735
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Carbidopa
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