cefpodoxime proxetil
1-propan-2-yloxycarbonyloxyethyl (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
Molecular Identity
cefpodoxime proxetil
1-propan-2-yloxycarbonyloxyethyl (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
PubChem CID: 6526396
Cefpodoxime proxetil is the 1-[(isopropoxycarbonyl)oxy]ethyl (proxetil) ester prodrug of cefpodoxime. After swallowing, hydrolysis of the ester group occurs in the intestinal epithelium, to release active cefpodoxime in the bloodstream. It is used to treat acute otitis media, pharyngitis, and sinusitis. It has a role as an antibacterial drug and a prodrug. It is a cephalosporin, a carboxylic ester and a carboxylic acid. It is functionally related to a cefpodoxime and a 4-{((R)-2-Carboxy-3-methoxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-en-7-ylcarbamoyl)-[(Z)-methoxyimino]-methyl}-thiazol-2-yl-ammonium.
2D Structure
Properties
C21H27N5O9S2
Molecular Formula
557.60
Molecular Weight
g/mol
557.1250
Exact Mass
Da
0.6
XLogP
Drug-like (Lipinski: < 5)
235
TPSA
May have limited oral absorption
2
H-Bond Donors
14
H-Bond Acceptors
976
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
cefpodoxime proxetil87239-81-4VantinBananOreloxOtreonCS-807SimplicefCefodoxU-76252Podomexef2TB00A1Z7NCHEBI:3505DTXSID1022766NSC-759161
Data from PubChem (NCBI)
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