Potassium Clavulanate
potassium (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylate
Molecular Identity
Potassium Clavulanate
potassium (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylate
PubChem CID: 23665591
Potassium clavulanate is a potassium salt having clavulanate as the counterion. It acts as a suicide inhibitor of bacterial beta-lactamase enzymes and has only weak anitbiotic activity when administered alone. However it can be used in combination with amoxicillin trihydrate (under the trade name Augmentin) for treatment of a variety of bacterial infections, where it prevents antibiotic inactivation by microbial lactamases. It has a role as an antimicrobial agent, an EC 3.5.2.6 (beta-lactamase) inhibitor and an antibacterial drug. It contains a clavulanate.
2D Structure
Properties
C8H8KNO5
Molecular Formula
237.25
Molecular Weight
g/mol
237.0040
Exact Mass
Da
89.9
TPSA
Good oral absorption (< 140 A²)
1
H-Bond Donors
5
H-Bond Acceptors
329
Complexity
SMILES
Canonical SMILES
SMILES: C1C2N(C1=O)C(C(=CCO)O2)C(=O)[O-].[K+]Isomeric SMILES
SMILES: C1[C@@H]2N(C1=O)[C@H](/C(=C/CO)/O2)C(=O)[O-].[K+]Synonyms(20)
Potassium clavulanate61177-45-5CLAVULANATE POTASSIUMAmonateBRL 14151KQ42OMW3AT8BRL-14151KCHEBI:85264DTXSID60210067AUGMENTIN COMPONENT CLAVULANATE POTASSIUM4-Oxa-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3-(2-hydroxyethylidene)-7-oxo-, monopotassium salt, (2R-(2alpha,3Z,5alpha))-Clavulanic Acid, Monopotassium SaltClavulanate, PotassiumPotassium, ClavulanateRefChem:56807
Data from PubChem (NCBI)
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Trials and conditions connected to Potassium Clavulanate
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