Clofarabine
(2R,3R,4S,5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol
Molecular Identity
Clofarabine
(2R,3R,4S,5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol
PubChem CID: 119182
Clofarabine is a purine nucleoside analogue consisting of a 6-amino-2-chloropurin-9-yl group attached to the 1beta position of 2'-deoxy-2'-fluoro-D-arabinofuranose. It is metabolized intracellularly to the active 5'-triphosphate metabolite, which inhibits DNA synthesisis and so stops the growth of cancer cells. Clofarabine is used as an antimetabolite antineoplastic agent in the treatment of relapsed or refractory acute lymphoblastic leukaemia. It has a role as an antimetabolite and an antineoplastic agent. It is a member of adenosines and an organofluorine compound.
2D Structure
Properties
C10H11ClFN5O3
Molecular Formula
303.68
Molecular Weight
g/mol
303.0534
Exact Mass
Da
0.9
XLogP
Drug-like (Lipinski: < 5)
119
TPSA
Good oral absorption (< 140 A²)
3
H-Bond Donors
8
H-Bond Acceptors
370
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
Clofarabine123318-82-1ClolarEvoltraClofarexCl-F-Ara-ACAFdAclofarabina(2R,3R,4S,5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-olclofarabinum2-Chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purin-6-amine9H-Purin-6-amine, 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-DTXSID50464372-Chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)adenine762RDY0Y2H
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Clofarabine
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