Molecular Identity
clofazimine
N,5-bis(4-chlorophenyl)-3-propan-2-yliminophenazin-2-amine
PubChem CID: 2794
Clofazimine is 3-Isopropylimino-3,5-dihydro-phenazine in which the hydrogen at position 5 is substituted substituted by a 4-chlorophenyl group, and that at position 2 is substituted by a (4-chlorophenyl)amino group. A dark red crystalline solid, clofazimine is an antimycobacterial and is one of the main drugs used for the treatment of multi-bacillary leprosy. However, it can cause red/brown discolouration of the skin, so other treatments are often preferred in light-skinned patients. It has a role as a non-steroidal anti-inflammatory drug, a leprostatic drug and a dye. It is a member of phenazines and a member of monochlorobenzenes.
2D Structure
Properties
C27H22Cl2N4
Molecular Formula
473.40
Molecular Weight
g/mol
472.1222
Exact Mass
Da
7.1
XLogP
Above Lipinski threshold
40
TPSA
Good oral absorption (< 140 A²)
1
H-Bond Donors
4
H-Bond Acceptors
829
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
clofazimine2030-63-9LampreneChlofazimineClofaziminaClofaziminumNSC-141046N,5-bis(4-chlorophenyl)-3-propan-2-yliminophenazin-2-amineG 30320DTXSID7022839ColfazimineG-303203-(p-Chloranilino)-10-(p-chlorphenyl)-2,10-dihydro-2-(isopropylimino)-phenazinD959AE5USF3-(p-Chloranilino)-10-(p-chlorophenyl)-2,10-dihydro-2-(isopropylimino)-phenazine
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to clofazimine
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