Molecular Identity
Clonazepam
5-(2-chlorophenyl)-7-nitro-1,3-dihydro-1,4-benzodiazepin-2-one
PubChem CID: 2802
Clonazepam is 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation. It has a role as an anxiolytic drug, an anticonvulsant and a GABA modulator. It is a 1,4-benzodiazepinone and a member of monochlorobenzenes.
2D Structure
Properties
C15H10ClN3O3
Molecular Formula
315.71
Molecular Weight
g/mol
315.0411
Exact Mass
Da
2.4
XLogP
Drug-like (Lipinski: < 5)
87.3
TPSA
Good oral absorption (< 140 A²)
1
H-Bond Donors
4
H-Bond Acceptors
491
Complexity
SMILES
Canonical SMILES
SMILES: C1C(=O)NC2=C(C=C(C=C2)[N+](=O)[O-])C(=N1)C3=CC=CC=C3ClIsomeric SMILES
SMILES: C1C(=O)NC2=C(C=C(C=C2)[N+](=O)[O-])C(=N1)C3=CC=CC=C3ClSynonyms(20)
clonazepamKlonopinRivotril1622-61-3ChlonazepamIktorivilCloazepamClonazepamumRavotrilRivatril5-(2-chlorophenyl)-7-nitro-1,3-dihydro-1,4-benzodiazepin-2-oneRo 4-8180Klonopin Rapidly DisintegratingClonazepam civ5-(2-Chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Clonazepam
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