Molecular Identity
Corticosterone
(8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
PubChem CID: 5753
Corticosterone is a 21-hydroxy steroid that consists of pregn-4-ene substituted by hydroxy groups at positions 11 and 21 and oxo groups at positions 3 and 20. Corticosterone is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands. It has a role as a mouse metabolite and a human metabolite. It is a primary alpha-hydroxy ketone, a glucocorticoid, a 21-hydroxy steroid, an 11beta-hydroxy steroid, a 20-oxo steroid, a 3-oxo-Delta(4) steroid and a C21-steroid. It derives from a hydride of a pregnane.
2D Structure
Properties
C21H30O4
Molecular Formula
346.50
Molecular Weight
g/mol
346.2144
Exact Mass
Da
1.9
XLogP
Drug-like (Lipinski: < 5)
74.6
TPSA
Good oral absorption (< 140 A²)
2
H-Bond Donors
4
H-Bond Acceptors
638
Complexity
SMILES
Canonical SMILES
SMILES: CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4C(=O)CO)C)OIsomeric SMILES
SMILES: C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@H]4C(=O)CO)C)OSynonyms(20)
CORTICOSTERONE50-22-617-DeoxycortisolReichstein's substance HKendall's compound BCorticosteron11beta,21-Dihydroxyprogesterone(11beta)-11,21-Dihydroxypregn-4-ene-3,20-dione11Beta,21-dihydroxypregn-4-ene-3,20-dioneNSC-970511beta,21-Dihydroxy-4-pregnene-3,20-dione4-Pregnene-11beta,21-diol-3,20-dioneDTXSID6022474CHEBI:16827W980KJ009P
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Corticosterone
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