Darizmetinib
N-[2,6-difluoro-3-(5-pyridin-4-yl-2H-pyrazolo[3,4-b]pyridine-3-carbonyl)phenyl]propane-1-sulfonamide
Molecular Identity
Darizmetinib
N-[2,6-difluoro-3-(5-pyridin-4-yl-2H-pyrazolo[3,4-b]pyridine-3-carbonyl)phenyl]propane-1-sulfonamide
PubChem CID: 139369660
2D Structure
Properties
C21H17F2N5O3S
Molecular Formula
457.50
Molecular Weight
g/mol
457.1020
Exact Mass
Da
3.1
XLogP
Drug-like (Lipinski: < 5)
126
TPSA
Good oral absorption (< 140 A²)
2
H-Bond Donors
9
H-Bond Acceptors
761
Complexity
SMILES
Canonical SMILES
SMILES: CCCS(=O)(=O)NC1=C(C=CC(=C1F)C(=O)C2=C3C=C(C=NC3=NN2)C4=CC=NC=C4)FIsomeric SMILES
SMILES: CCCS(=O)(=O)NC1=C(C=CC(=C1F)C(=O)C2=C3C=C(C=NC3=NN2)C4=CC=NC=C4)FSynonyms(20)
Darizmetinib2369583-33-3HRX-0215N-(2,6-Difluoro-3-(5-(pyridin-4-yl)-1H-pyrazolo[3,4-b]pyridine-3-carbonyl)phenyl)propane-1-sulfonamideLN3348HRX215LN-3348N-[2,6-difluoro-3-(5-pyridin-4-yl-2H-pyrazolo[3,4-b]pyridine-3-carbonyl)phenyl]propane-1-sulfonamideN-{2,6-Difluoro-3-[5-(pyridin-4-yl)-1H-pyrazolo[3,4-b]pyridine-3-carbonyl]phenyl}propane-1-sulfonamidedarizmetinib [INN]Q2HX6A3UDWorb1980154CHEMBL4795907SCHEMBL21223057SCHEMBL30597794
Data from PubChem (NCBI)
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