Didanosine
9-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]-1H-purin-6-one
Molecular Identity
Didanosine
9-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]-1H-purin-6-one
PubChem CID: 135398739
Didanosine is a purine 2',3'-dideoxyribonucleoside that is inosine in which the hydroxy groups at both the 2' and the 3' positions on the sugar moiety have been replaced by hydrogen. An antiviral drug, it is used as a medication to treat HIV/AIDS. It has a role as a geroprotector, an antimetabolite, an antiviral drug, a HIV-1 reverse transcriptase inhibitor and an EC 2.4.2.1 (purine-nucleoside phosphorylase) inhibitor.
2D Structure
Properties
C10H12N4O3
Molecular Formula
236.23
Molecular Weight
g/mol
236.0909
Exact Mass
Da
-1.2
XLogP
Drug-like (Lipinski: < 5)
88.7
TPSA
Good oral absorption (< 140 A²)
2
H-Bond Donors
5
H-Bond Acceptors
348
Complexity
SMILES
Canonical SMILES
SMILES: C1CC(OC1CO)N2C=NC3=C2N=CNC3=OIsomeric SMILES
SMILES: C1C[C@@H](O[C@@H]1CO)N2C=NC3=C2N=CNC3=OSynonyms(20)
didanosine2',3'-Dideoxyinosine69655-05-6DIDEOXYINOSINEVidexInosine, 2',3'-dideoxy-Videx ECDidanosinaDidanosinumddIno2,3-dideoxyinosineBMY-40900(-)-didanosineDTXSID6022927NSC-612049
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Didanosine
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