Dorzagliatin
(2S)-2-[3-(2-chlorophenoxy)-5-oxo-2H-pyrrol-1-yl]-N-[1-[(2R)-2,3-dihydroxypropyl]pyrazol-3-yl]-4-methylpentanamide
Molecular Identity
Dorzagliatin
(2S)-2-[3-(2-chlorophenoxy)-5-oxo-2H-pyrrol-1-yl]-N-[1-[(2R)-2,3-dihydroxypropyl]pyrazol-3-yl]-4-methylpentanamide
PubChem CID: 57920094
Dorzagliatin is a secondary carboxamide resulting from the formal condensation of the carboxy group of (2S)-2-[4-(2-chlorophenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl]-4-methylpentanoic acid with the amino group of (2R)-3-(3-amino-1H-pyrrol-1-yl)propane-1,2-diol. It is an allosteric glucokinase activator developed by Hua Medicine for the treatment of type 1 and 2 diabetes mellitus , and diabetic kidney disease. It has a role as an enzyme activator and a hypoglycemic agent. It is a secondary carboxamide, a primary alcohol, a pyrroline, a diol, a member of pyrazoles, an aromatic ether, a secondary alcohol, a tertiary amino compound, an enone and a member of monochlorobenzenes.
2D Structure
Properties
C22H27ClN4O5
Molecular Formula
462.90
Molecular Weight
g/mol
462.1670
Exact Mass
Da
1.6
XLogP
Drug-like (Lipinski: < 5)
117
TPSA
Good oral absorption (< 140 A²)
3
H-Bond Donors
6
H-Bond Acceptors
691
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
Dorzagliatin1191995-00-2HMS5552HMS-5552dorzagliatinadorzagliatineSinogliatindorzagliatinumRO5305552RO-5305552X59W6980E8(2S)-2-[4-(2-chlorophenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl]-N-{1-[(2R)-2,3-dihydroxypropyl]-1H-pyrazol-3-yl}-4-methylpentanamide(2S)-2-(4-(2-chlorophenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(1-((2R)-2,3-dihydroxypropyl)-1H-pyrazol-3-yl)-4-methylpentanamide1H-Pyrrole-1-acetamide, 4-(2-chlorophenoxy)-N-(1-((2R)-2,3-dihydroxypropyl)-1H-pyrazol-3-yl)-2,5-dihydro-alpha-(2-methylpropyl)-2-oxo-, (alphaS)-RefChem:135682
Data from PubChem (NCBI)
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