Molecular Identity
Droperidol
3-[1-[4-(4-fluorophenyl)-4-oxobutyl]-3,6-dihydro-2H-pyridin-4-yl]-1H-benzimidazol-2-one
PubChem CID: 3168
Droperidol is an organofluorine compound that is haloperidol in which the hydroxy group has been eliminated with the introduction of a double bond in the piperidine ring, and the 4-chlorophenyl group has been replaced by a benzimidazol-2-on-1-yl group. It is used in the management of chemotherapy-induced nausea and vomiting, and in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It has a role as a dopaminergic antagonist, an antiemetic, an anaesthesia adjuvant and a first generation antipsychotic. It is a member of benzimidazoles, an organofluorine compound and an aromatic ketone.
2D Structure
Properties
C22H22FN3O2
Molecular Formula
379.40
Molecular Weight
g/mol
379.1696
Exact Mass
Da
3.5
XLogP
Drug-like (Lipinski: < 5)
52.7
TPSA
Good oral absorption (< 140 A²)
1
H-Bond Donors
4
H-Bond Acceptors
615
Complexity
SMILES
Canonical SMILES
SMILES: C1CN(CC=C1N2C3=CC=CC=C3NC2=O)CCCC(=O)C4=CC=C(C=C4)FIsomeric SMILES
SMILES: C1CN(CC=C1N2C3=CC=CC=C3NC2=O)CCCC(=O)C4=CC=C(C=C4)FSynonyms(20)
droperidol548-73-2DroleptanDehydrobenzperidolInapsineDridolProperidolSintodrilSintosianHalkanInapsinDeidrobenzperidoloInopsinMcN-JR-4749Droperidolo
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Droperidol
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