Azilsartan Medoxomil
(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-3-[[4-[2-(5-oxo-4H-1,2,4-oxadiazol-3-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylate
Molecular Identity
Azilsartan Medoxomil
(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-3-[[4-[2-(5-oxo-4H-1,2,4-oxadiazol-3-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylate
PubChem CID: 135409642
Azilsartan medoxomil is a carboxylic ester obtained by formal condensation of the carboxy group of azilsartan with the hydroxy group of 4-(hydroxymethyl)-5-methyl-1,3-dioxol-2-one. A prodrug for azilsartan, it is used for treatment of hypertension. It has a role as an antihypertensive agent, a prodrug and an angiotensin receptor antagonist. It is a member of benzimidazoles, a carboxylic ester, an aromatic ether, a dioxolane, a 1,2,4-oxadiazole and a cyclic carbonate ester. It is functionally related to an azilsartan. It is a conjugate acid of an azilsartan medoxomil(1-).
2D Structure
Properties
C30H24N4O8
Molecular Formula
568.50
Molecular Weight
g/mol
568.1594
Exact Mass
Da
4.9
XLogP
Drug-like (Lipinski: < 5)
140
TPSA
May have limited oral absorption
1
H-Bond Donors
10
H-Bond Acceptors
1100
Complexity
SMILES
Canonical SMILES
SMILES: CCOC1=NC2=CC=CC(=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NOC(=O)N5)C(=O)OCC6=C(OC(=O)O6)CIsomeric SMILES
SMILES: CCOC1=NC2=CC=CC(=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NOC(=O)N5)C(=O)OCC6=C(OC(=O)O6)CSynonyms(20)
AZILSARTAN MEDOXOMIL863031-21-4TAK 491TAK-491azilsartan medoxomiloIprezivAR-14LL0G25K7I2azilsartanum medoxomilumTAK491CHEBI:68845DTXSID10235482(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-3-[[4-[2-(5-oxo-2H-1,2,4-oxadiazol-3-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylate(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-1-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-1-benzimidazole-7-carboxylate1H-Benzimidazole-7-carboxylic acid, 1-((2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)(1,1'-biphenyl)-4-yl)methyl)-2-ethoxy-, (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester
Data from PubChem (NCBI)
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