Ergometrine

Ergometrine

(6aR,9R)-N-[(2S)-1-hydroxypropan-2-yl]-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide

PubChem CID: 443884

Ergometrine is a monocarboxylic acid amide that is lysergamide in which one of the hydrogens attached to the amide nitrogen is substituted by a 1-hydroxypropan-2-yl group (S-configuration). An ergot alkaloid that has a particularly powerful action on the uterus, its maleate (and formerly tartrate) salt is used in the active management of the third stage of labour, and to prevent or treat postpartum of postabortal haemorrhage caused by uterine atony: by maintaining uterine contraction and tone, blood vessels in the uterine wall are compressed and blood flow reduced. It has a role as a toxin, a diagnostic agent, an oxytocic and a fungal metabolite. It is a primary alcohol, an ergot alkaloid, a monocarboxylic acid amide, an organic heterotetracyclic compound, a secondary amino compound and a tertiary amino compound. It derives from a hydride of an ergoline.

2D Structure

Properties

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Synonyms(20)