Eribulin mesylate
(1S,3S,6S,9S,12S,14R,16R,18S,20R,21R,22S,26R,29S,31R,32S,33R,35R,36S)-20-[(2S)-3-amino-2-hydroxypropyl]-21-methoxy-14-methyl-8,15-dimethylidene-2,19,30,34,37,39,40,41-octaoxanonacyclo[24.9.2.13,32.13,33.16,9.112,16.018,22.029,36.031,35]hentetracontan-24-one;methanesulfonic acid
Molecular Identity
Eribulin mesylate
(1S,3S,6S,9S,12S,14R,16R,18S,20R,21R,22S,26R,29S,31R,32S,33R,35R,36S)-20-[(2S)-3-amino-2-hydroxypropyl]-21-methoxy-14-methyl-8,15-dimethylidene-2,19,30,34,37,39,40,41-octaoxanonacyclo[24.9.2.13,32.13,33.16,9.112,16.018,22.029,36.031,35]hentetracontan-24-one;methanesulfonic acid
PubChem CID: 17755248
Eribulin mesylate is a methanesulfonate salt obtained by reaction of eribulin with one equivalent of methanesulfonic acid. A fully synthetic macrocyclic ketone analogue of marine sponge natural products. Inhibits growth phase of microtubules via tubulin-based antimitotic mechanism, which leads to G2/M cell-cycle block, disruption of mitotic spindles, and, ultimately, apoptotic cell death after prolonged mitotic blockage. It has a role as an antineoplastic agent and a microtubule-destabilising agent. It contains an eribulin(1+).
2D Structure
Properties
C41H63NO14S
Molecular Formula
826.00
Molecular Weight
g/mol
825.3969
Exact Mass
Da
209
TPSA
May have limited oral absorption
3
H-Bond Donors
15
H-Bond Acceptors
1470
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
Eribulin mesylate441045-17-6HalavenEribulin mesilateEribulin (as mesylate)E7389Eribulin monomethanesulfonateAV9U0660CWE-7389CHEBI:70710NSC707389B1939 mesylateHalichondrin B AnalogRefChem:56931Eribulin (mesylate)
Data from PubChem (NCBI)
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Trials and conditions connected to Eribulin mesylate
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