FHD-286
N-[(2S)-1-[[4-[6-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2-pyridinyl]-1,3-thiazol-2-yl]amino]-3-methoxy-1-oxopropan-2-yl]-1-methylsulfonylpyrrole-3-carboxamide
Molecular Identity
FHD-286
N-[(2S)-1-[[4-[6-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2-pyridinyl]-1,3-thiazol-2-yl]amino]-3-methoxy-1-oxopropan-2-yl]-1-methylsulfonylpyrrole-3-carboxamide
PubChem CID: 156818030
FHD-286 is a selective, oral inhibitor of SMARCA4/SMARCA2 ATPase (BRG1 and BRM) inhibitor. FHD-286 has the potential for the research of BAF (BRG1/BRM-associated factor)-related disorders such as acute myeloid leukemia.
2D Structure
Properties
C24H30N6O6S2
Molecular Formula
562.70
Molecular Weight
g/mol
562.1668
Exact Mass
Da
1.3
XLogP
Drug-like (Lipinski: < 5)
181
TPSA
May have limited oral absorption
2
H-Bond Donors
10
H-Bond Acceptors
926
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
FHD-2862671128-05-31H-Pyrrole-3-carboxamide, N-((1S)-2-((4-(6-((2R,6S)-2,6-dimethyl-4-morpholinyl)-2-pyridinyl)-2-thiazolyl)amino)-1-(methoxymethyl)-2-oxoethyl)-1-(methylsulfonyl)-N-[(2S)-1-[[4-[6-[(2S,6R)-2,6-dimethylmorpholin-4-yl]pyridin-2-yl]-1,3-thiazol-2-yl]amino]-3-methoxy-1-oxopropan-2-yl]-1-methylsulfonylpyrrole-3-carboxamideFHD 2861H-Pyrrole-3-carboxamide, N-[(1S)-2-[[4-[6-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-2-pyridinyl]-2-thiazolyl]amino]-1-(methoxymethyl)-2-oxoethyl]-1-(methylsulfonyl)-N-((2S)-1-((4-(6-((2S,6R)-2,6-dimethylmorpholin-4-yl)pyridin-2-yl)-1,3-thiazol-2-yl)amino)-3-methoxy-1-oxopropan-2-yl)-1-methylsulfonylpyrrole-3-carboxamideRefChem:140373BRG1/BRM Inhibitor FHD-286SMARCA4/SMARCA2 ATPase Inhibitor FHD-286CamibirstatQHA5XLA4SAUNII-QHA5XLA4SAFHD286N-((S)-1-((4-(6-((2R,6S)-2,6-Dimethylmorpholino)pyridin-2-yl)thiazol-2-yl)amino)-3-methoxy-1-oxopropan-2-yl)-1-(methylsulfonyl)-1H-pyrrole-3-carboxamide
Data from PubChem (NCBI)
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