Febuxostat
2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylic acid
Molecular Identity
Febuxostat
2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylic acid
PubChem CID: 134018
Febuxostat is a 1,3-thiazolemonocarboxylic acid that is 4-methyl-1,3-thiazole-5-carboxylic acid which is substituted by a 3-cyano-4-(2-methylpropoxy)phenyl group at position 2. It is an orally-active, potent, and selective xanthine oxidase inhibitor used for the treatment of chronic hyperuricaemia in patients with gout. It has a role as an EC 1.17.3.2 (xanthine oxidase) inhibitor. It is a nitrile, an aromatic ether and a 1,3-thiazolemonocarboxylic acid.
2D Structure
Properties
C16H16N2O3S
Molecular Formula
316.40
Molecular Weight
g/mol
316.0882
Exact Mass
Da
3.9
XLogP
Drug-like (Lipinski: < 5)
111
TPSA
Good oral absorption (< 140 A²)
1
H-Bond Donors
6
H-Bond Acceptors
448
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
Febuxostat144060-53-7AdenuricUloricTMX-67Tei 6720Tei-67202-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylic acidTMX 67ZurigFebuxostatumNSC-758874DTXSID8048650101V0R1N2E5-Thiazolecarboxylic acid, 2-(3-cyano-4-(2-methylpropoxy)phenyl)-4-methyl-
Data from PubChem (NCBI)
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Drug Network
Trials and conditions connected to Febuxostat
Loading drug network...