Molecular Identity
felodipine
5-O-ethyl 3-O-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
PubChem CID: 3333
Felodipine is the mixed (methyl, ethyl) diester of 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium-channel blocker, it lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth muscle in arteriolar resistance vessels. It is used in the management of hypertension and angina pectoris. It has a role as a vasodilator agent, an antihypertensive agent, an anti-arrhythmia drug and a calcium channel blocker. It is a dichlorobenzene, an ethyl ester, a methyl ester and a dihydropyridine.
2D Structure
Properties
C18H19Cl2NO4
Molecular Formula
384.20
Molecular Weight
g/mol
383.0691
Exact Mass
Da
3.9
XLogP
Drug-like (Lipinski: < 5)
64.6
TPSA
Good oral absorption (< 140 A²)
1
H-Bond Donors
5
H-Bond Acceptors
614
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
felodipine72509-76-3PlendilFlodilModipFelodipinaPreslowFelodipinumH 154/82FelodipinoDTXSID4023042NSC-760343OL961R6O2C4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethyl methyl esterC08CA02
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to felodipine
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