Molecular Identity
Flecainide
N-(piperidin-2-ylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide
PubChem CID: 3356
Flecainide is a monocarboxylic acid amide obtained by formal condensation of the carboxy group of 2,5-bis(2,2,2-trifluoroethoxy)benzoic acid with the primary amino group of piperidin-2-ylmethylamine. An antiarrhythmic agent used (in the form of its acetate salt) to prevent and treat tachyarrhythmia (abnormal fast rhythm of the heart). It has a role as an anti-arrhythmia drug. It is a member of piperidines, a monocarboxylic acid amide, an aromatic ether and an organofluorine compound. It is a conjugate base of a flecainide(1+).
2D Structure
Properties
C17H20F6N2O3
Molecular Formula
414.34
Molecular Weight
g/mol
414.1378
Exact Mass
Da
3.8
XLogP
Drug-like (Lipinski: < 5)
59.6
TPSA
Good oral absorption (< 140 A²)
2
H-Bond Donors
10
H-Bond Acceptors
500
Complexity
SMILES
Canonical SMILES
SMILES: C1CCNC(C1)CNC(=O)C2=C(C=CC(=C2)OCC(F)(F)F)OCC(F)(F)FIsomeric SMILES
SMILES: C1CCNC(C1)CNC(=O)C2=C(C=CC(=C2)OCC(F)(F)F)OCC(F)(F)FSynonyms(20)
flecainide54143-55-4FlecaineN-(piperidin-2-ylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamideFlecainidaFlecainidum(+-)-FlecainideN-(2-Piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamideCCRIS 313Benzamide, N-(2-piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)-DTXSID8023054NSC-719273K94FTS1806DTXCID403054CHEBI:75984
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Flecainide
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