Molecular Identity
flurazepam
7-chloro-1-[2-(diethylamino)ethyl]-5-(2-fluorophenyl)-3H-1,4-benzodiazepin-2-one
PubChem CID: 3393
Flurazepam is a 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a 2-(diethylamino)ethyl group, 2-fluorophenyl group and chloro group at positions 1, 5 and 7, respectively. It is a partial agonist of GABAA receptors and used for the treatment of insomnia. It has a role as an anxiolytic drug, an anticonvulsant, a sedative and a GABAA receptor agonist. It is a 1,4-benzodiazepinone, an organochlorine compound, a tertiary amino compound and a member of monofluorobenzenes.
2D Structure
Properties
C21H23ClFN3O
Molecular Formula
387.90
Molecular Weight
g/mol
387.1514
Exact Mass
Da
3
XLogP
Drug-like (Lipinski: < 5)
35.9
TPSA
Good oral absorption (< 140 A²)
0
H-Bond Donors
4
H-Bond Acceptors
540
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
flurazepam17617-23-1InsuminFlurazepamumDalmane-RFelisonRo-5-6901/3DTXSID1023071IHP475989U7-Chloro-1-[2-(diethylamino)ethyl]-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one7-Chloro-1-(2-(diethylamino)ethyl)-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-oneCHEBI:5128DTXCID8030712H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-1-(2-(diethylamino)ethyl)-5-(o-fluorophenyl)-2H-1,4-Benzodiazepin-2-one, 7-chloro-1-(2-(diethylamino)ethyl)-5-(2-fluorophenyl)-1,3-dihydro-
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to flurazepam
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