Foretinib
1-N'-[3-fluoro-4-[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxyphenyl]-1-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
Molecular Identity
Foretinib
1-N'-[3-fluoro-4-[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxyphenyl]-1-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
PubChem CID: 42642645
Foretinib is a quinoline substituted by 2-fluoro-4-[({1-[(4-fluorophenyl)carbamoyl]cyclopropyl}carbonyl)amino]phenoxy, methoxy, and 3-(morpholin-4-yl)propoxy groups at positions 4, 6 and 7, respectively. It is a multi-kinase inhibitor. It has a role as an antineoplastic agent, a vascular endothelial growth factor receptor antagonist, an apoptosis inducer and a c-Met tyrosine kinase inhibitor. It is a member of quinolines, an aromatic ether, a dicarboxylic acid diamide, a member of morpholines, a member of cyclopropanes and a member of monofluorobenzenes.
2D Structure
Properties
C34H34F2N4O6
Molecular Formula
632.70
Molecular Weight
g/mol
632.2446
Exact Mass
Da
5.5
XLogP
Above Lipinski threshold
111
TPSA
Good oral absorption (< 140 A²)
2
H-Bond Donors
10
H-Bond Acceptors
1010
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
Foretinib849217-64-7GSK1363089XL880EXEL-2880XL-880GSK 1363089GSK089GSK-1363089GSK-089GSK1363089G81FH7VK1C4GSK-1363089GDTXSID20918193937176-80-2
Data from PubChem (NCBI)
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Trials and conditions connected to Foretinib
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