Molecular Identity
foscarnet
phosphonoformic acid
PubChem CID: 3415
Phosphonoformic acid is phosphoric acid in which one of the hydroxy groups is replaced by a carboxylic acid group. It is used as the trisodium salt as an antiviral agent in the treatment of cytomegalovirus retinitis (CMV retinitis, an inflamation of the retina that can lead to blindness) and as an alternative to ganciclovir for AIDS patients who require concurrent antiretroviral therapy but are unable to tolerate ganciclovir due to haematological toxicity. It has a role as a geroprotector, an antiviral drug, a HIV-1 reverse transcriptase inhibitor and a sodium-dependent Pi-transporter inhibitor. It is a member of phosphonic acids, a carboxylic acid and a one-carbon compound. It is functionally related to a formic acid and a phosphonic acid. It is a conjugate acid of a phosphonatoformate and a phosphonoformate(2-).
2D Structure
Properties
CH3O5P
Molecular Formula
126.01
Molecular Weight
g/mol
125.9718
Exact Mass
Da
-2
XLogP
Drug-like (Lipinski: < 5)
94.8
TPSA
Good oral absorption (< 140 A²)
3
H-Bond Donors
5
H-Bond Acceptors
120
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
foscarnetPhosphonoformic acidPhosphonoformateCarboxyphosphonic acid4428-95-9Foscarmetphosphonocarboxylic acidphosphonomethanoic acid364P9RVW4XJ05AD01Phosphinecarboxylic acid, dihydroxy-, oxideDTXSID0048478CHEBI:127780RefChem:55232DTXCID0028452
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to foscarnet
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