Perampanel
2-(2-oxo-1-phenyl-5-pyridin-2-yl-3-pyridinyl)benzonitrile
Molecular Identity
Perampanel
2-(2-oxo-1-phenyl-5-pyridin-2-yl-3-pyridinyl)benzonitrile
PubChem CID: 9924495
Perampanel is a member of the class of bipyridines that is 2,3'-bipyridin-6'-one substituted at positions 1' and 5' by phenyl and 2-cyanophenyl groups respectively. Used as an adjunctive therapy for the treatment of partial-onset seizures in patients with epilepsy. It has a role as an anticonvulsant and an AMPA receptor antagonist. It is a nitrile, a pyridone and a member of bipyridines. It is functionally related to a benzonitrile.
2D Structure
Properties
C23H15N3O
Molecular Formula
349.40
Molecular Weight
g/mol
349.1215
Exact Mass
Da
3.4
XLogP
Drug-like (Lipinski: < 5)
57
TPSA
Good oral absorption (< 140 A²)
0
H-Bond Donors
3
H-Bond Acceptors
664
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
Perampanel380917-97-5FycompaE2007ER-155055-90E-2007perampanelumE 20073-(2-Cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one2-(2-oxo-1-phenyl-5-pyridin-2-ylpyridin-3-yl)benzonitrileCHEBI:71013H821664NPKBenzonitrile, 2-(1',6'-dihydro-6'-oxo-1'-phenyl[2,3'-bipyridin]-5'-yl)-DTXSID801915012-(6'-oxo-1'-phenyl-1',6'-dihydro-2,3'-bipyridin-5'-yl)benzonitrile
Data from PubChem (NCBI)
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