Gdc-0134
3-(difluoromethoxy)-5-[2-(3,3-difluoropyrrolidin-1-yl)-6-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]pyrimidin-4-yl]pyridin-2-amine
Molecular Identity
Gdc-0134
3-(difluoromethoxy)-5-[2-(3,3-difluoropyrrolidin-1-yl)-6-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]pyrimidin-4-yl]pyridin-2-amine
PubChem CID: 86298636
2D Structure
Properties
C19H20F4N6O2
Molecular Formula
440.40
Molecular Weight
g/mol
440.1584
Exact Mass
Da
3
XLogP
Drug-like (Lipinski: < 5)
89.6
TPSA
Good oral absorption (< 140 A²)
1
H-Bond Donors
12
H-Bond Acceptors
649
Complexity
SMILES
Canonical SMILES
SMILES: C1CN(CC1(F)F)C2=NC(=CC(=N2)N3CC4CC3CO4)C5=CC(=C(N=C5)N)OC(F)FIsomeric SMILES
SMILES: C1CN(CC1(F)F)C2=NC(=CC(=N2)N3C[C@@H]4C[C@H]3CO4)C5=CC(=C(N=C5)N)OC(F)FSynonyms(20)
GDC-0134RG-60001637394-01-44N6KQ7D685GDC01342-Pyridinamine, 3-(difluoromethoxy)-5-(2-(3,3-difluoro-1-pyrrolidinyl)-6-(1S,4S)-2-oxa-5-azabicyclo(2.2.1)hept-5-yl-4-pyrimidinyl)-compound 279 (WO2014177060A1)compound 279 [WO2014177060A1]RefChem:142760UNII-4N6KQ7D685orb2815663CHEMBL3732012SCHEMBL16210454SCHEMBL29374456SCHEMBL29569344
Data from PubChem (NCBI)
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Trials and conditions connected to Gdc-0134
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