Gdc-0623
5-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide
Molecular Identity
Gdc-0623
5-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide
PubChem CID: 42642654
GDC-0623 is a member of the class of imidazopyridines that is imidazo[1,5-a]pyridine substituted by (2-fluoro-4-iodophenyl)amino and (2-hydroxyethoxy)aminoacyl groups at positions 5 and 6. It is a potent ATP non-competitive inhibitor of MEK1 (Ki = 0.13nM) and also has efficacy against both mutant BRAF and mutant KRAS. It is in clinical development for treatment of patients with locally advanced or metastatic solid tumors. It has a role as an antineoplastic agent, an apoptosis inducer and an EC 2.7.12.2 (mitogen-activated protein kinase kinase) inhibitor. It is a primary alcohol, an organoiodine compound, an imidazopyridine, a substituted aniline, a secondary amino compound, a hydroxamic acid ester and a member of monofluorobenzenes.
2D Structure
Properties
C16H14FIN4O3
Molecular Formula
456.21
Molecular Weight
g/mol
456.0095
Exact Mass
Da
3.7
XLogP
Drug-like (Lipinski: < 5)
87.9
TPSA
Good oral absorption (< 140 A²)
3
H-Bond Donors
6
H-Bond Acceptors
461
Complexity
SMILES
Canonical SMILES
SMILES: C1=CC(=C(C=C1I)F)NC2=C(C=CC3=CN=CN32)C(=O)NOCCOIsomeric SMILES
SMILES: C1=CC(=C(C=C1I)F)NC2=C(C=CC3=CN=CN32)C(=O)NOCCOSynonyms(20)
GDC-06231168091-68-6GDC 0623GDC06235-((2-FLUORO-4-IODOPHENYL)AMINO)-N-(2-HYDROXYETHOXY)IMIDAZO[1,5-A]PYRIDINE-6-CARBOXAMIDERG 7421HW67545I4QG-868RG-7421CHEBI:1676595-[(2-FLUORO-4-IODOPHENYL)AMINO]-N-(2-HYDROXYETHOXY)IMIDAZO[1,5-A]PYRIDINE-6-CARBOXAMIDE5-((2-fluoro-4-iodophenyl)amino)-N-(2-hydroxyethoxy)imidazo(1,5-a)pyridine-6-carboxamideRefChem:142766MEK INHIBITOR GDC-0623MFCD25976760
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Gdc-0623
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