Molecular Identity
Glipizide
N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-5-methylpyrazine-2-carboxamide
PubChem CID: 3478
Glipizide is an N-sulfonylurea that is glyburide in which the (5-chloro-2-methoxybenzoyl group is replaced by a (5-methylpyrazin-2-yl)carbonyl group. An oral hypoglycemic agent, it is used in the treatment of type 2 diabetes mellitus. It has a role as a hypoglycemic agent, an EC 2.7.1.33 (pantothenate kinase) inhibitor and an insulin secretagogue. It is a monocarboxylic acid amide, a member of pyrazines, an aromatic amide and a N-sulfonylurea.
2D Structure
Properties
C21H27N5O4S
Molecular Formula
445.50
Molecular Weight
g/mol
445.1784
Exact Mass
Da
1.9
XLogP
Drug-like (Lipinski: < 5)
139
TPSA
Good oral absorption (< 140 A²)
3
H-Bond Donors
6
H-Bond Acceptors
697
Complexity
SMILES
Canonical SMILES
SMILES: CC1=CN=C(C=N1)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCCCC3Isomeric SMILES
SMILES: CC1=CN=C(C=N1)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCCCC3Synonyms(20)
glipizide29094-61-9GlucotrolGlydiazinamideGlibeneseMelizideMinidiabMinodiabDipazideGlucozideGlupitelGlupizideNapizideSucrazideMindiab
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Glipizide
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