Gsk-1059615
(5Z)-5-[(4-pyridin-4-ylquinolin-6-yl)methylidene]-1,3-thiazolidine-2,4-dione
Molecular Identity
Gsk-1059615
(5Z)-5-[(4-pyridin-4-ylquinolin-6-yl)methylidene]-1,3-thiazolidine-2,4-dione
PubChem CID: 23582824
GSK1059615 is a thiazolidinone that is the 5-{[4-(pyridin-4-yl)quinolin-6-yl]methylene} derivative of 1,3-thiazolidine-2,4-dione. A PI3K inhibitor. It has a role as an antineoplastic agent and an EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor. It is a member of pyridines, a member of quinolines and a thiazolidinone.
2D Structure
Properties
C18H11N3O2S
Molecular Formula
333.40
Molecular Weight
g/mol
333.0572
Exact Mass
Da
3
XLogP
Drug-like (Lipinski: < 5)
97.3
TPSA
Good oral absorption (< 140 A²)
1
H-Bond Donors
5
H-Bond Acceptors
544
Complexity
SMILES
Canonical SMILES
SMILES: C1=CC2=NC=CC(=C2C=C1C=C3C(=O)NC(=O)S3)C4=CC=NC=C4Isomeric SMILES
SMILES: C1=CC2=NC=CC(=C2C=C1/C=C\3/C(=O)NC(=O)S3)C4=CC=NC=C4Synonyms(20)
GSK1059615GSK-1059615GSK 1059615GSK-615GSK615UNII-07YMO87363(5Z)-5-[(4-pyridin-4-ylquinolin-6-yl)methylidene]-1,3-thiazolidine-2,4-dioneCHEBI:71955DTXSID00242004(5Z)-5-{[4-(pyridin-4-yl)quinolin-6-yl]methylidene}-1,3-thiazolidine-2,4-dione5-{[4-(pyridin-4-yl)quinolin-6-yl]methylene}-1,3-thiazolidine-2,4-dione2,4-THIAZOLIDINEDIONE, 5-((4-(4-PYRIDINYL)-6-QUINOLINYL)METHYLENE)-, (5Z)-5-((4-(pyridin-4-yl)quinolin-6-yl)methylene)-1,3-thiazolidine-2,4-dione(5Z)-5-((4-(pyridin-4-yl)quinolin-6-yl)methylidene)-1,3-thiazolidine-2,4-dione(5Z)-5-((4-pyridin-4-ylquinolin-6-yl)methylidene)-1,3-thiazolidine-2,4-dione
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Gsk-1059615
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