Pemrametostat
6-[(1-acetylpiperidin-4-yl)amino]-N-[(2S)-3-(3,4-dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]pyrimidine-4-carboxamide
Molecular Identity
Pemrametostat
6-[(1-acetylpiperidin-4-yl)amino]-N-[(2S)-3-(3,4-dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]pyrimidine-4-carboxamide
PubChem CID: 90241742
2D Structure
Properties
C24H32N6O3
Molecular Formula
452.50
Molecular Weight
g/mol
452.2536
Exact Mass
Da
1.1
XLogP
Drug-like (Lipinski: < 5)
111
TPSA
Good oral absorption (< 140 A²)
3
H-Bond Donors
7
H-Bond Acceptors
656
Complexity
SMILES
Canonical SMILES
SMILES: CC(=O)N1CCC(CC1)NC2=NC=NC(=C2)C(=O)NCC(CN3CCC4=CC=CC=C4C3)OIsomeric SMILES
SMILES: CC(=O)N1CCC(CC1)NC2=NC=NC(=C2)C(=O)NC[C@@H](CN3CCC4=CC=CC=C4C3)OSynonyms(20)
1616392-22-3GSK3326595PemrametostatGSK-3326595EPZ015938VXT8SZ6875GSK-3326595AEPZ-015938PROTEIN ARGININE METHYLTRANSFERASE 5 INHIBITOR GSK33265954-pyrimidinecarboxamide, 6-((1-acetyl-4-piperidinyl)amino)-N-(3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl)-RefChem:170734PRMT5 Inhibitor GSK33265956-[(1-acetylpiperidin-4-yl)amino]-N-[(2S)-2-hydroxy-3-(1,2,3,4-tetrahydroisoquinolin-2-yl)propyl]pyrimidine-4-carboxamide(S)-6-((1-acetylpiperidin-4-yl)amino)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)pyrimidine-4-carboxamideMFCD29991177
Data from PubChem (NCBI)
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Drug Network
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