Ginsenoside Rg3
(2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5S,6R)-4,5-dihydroxy-2-[[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-hydroxy-17-[(2S)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol
Molecular Identity
Ginsenoside Rg3
(2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5S,6R)-4,5-dihydroxy-2-[[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-hydroxy-17-[(2S)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol
PubChem CID: 9918693
(20S)-ginsenoside Rg3 is a ginsenoside found in Panax ginseng and Panax japonicus var. major that is dammarane which is substituted by hydroxy groups at the 3beta, 12beta and 20 pro-S positions, in which the hydroxy group at position 3 has been converted to the corresponding beta-D-glucopyranosyl-beta-D-glucopyranoside, and in which a double bond has been introduced at the 24-25 position. It has a role as an antineoplastic agent, an angiogenesis modulating agent, an apoptosis inducer and a plant metabolite. It is a glycoside, a tetracyclic triterpenoid and a ginsenoside. It is functionally related to a (20S)-protopanaxadiol. It derives from a hydride of a dammarane.
2D Structure
Properties
C42H72O13
Molecular Formula
785.00
Molecular Weight
g/mol
784.4973
Exact Mass
Da
4
XLogP
Drug-like (Lipinski: < 5)
219
TPSA
May have limited oral absorption
9
H-Bond Donors
13
H-Bond Acceptors
1370
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
Ginsenoside Rg314197-60-5(20S)-ginsenoside Rg3(20S)-Propanaxadiol20S-propanaxadiol20s-ginsenoside rg3S-Ginsenoside Rg3ginsenoside 20-rg3ginsenoside rg3, (s)-ginsenoside rg3, (+)-227D367Y57CHEBI:67991DTXSID101316982(2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5S,6R)-4,5-dihydroxy-2-[[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-hydroxy-17-[(2S)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triolginsenoside Rg(3)
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Ginsenoside Rg3
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