H3b-6527
N-[2-[[6-[(2,6-dichloro-3,5-dimethoxyphenyl)carbamoyl-methylamino]pyrimidin-4-yl]amino]-5-(4-ethylpiperazin-1-yl)phenyl]prop-2-enamide
Molecular Identity
H3b-6527
N-[2-[[6-[(2,6-dichloro-3,5-dimethoxyphenyl)carbamoyl-methylamino]pyrimidin-4-yl]amino]-5-(4-ethylpiperazin-1-yl)phenyl]prop-2-enamide
PubChem CID: 118029202
2D Structure
Properties
C29H34Cl2N8O4
Molecular Formula
629.50
Molecular Weight
g/mol
628.2080
Exact Mass
Da
4.4
XLogP
Drug-like (Lipinski: < 5)
124
TPSA
Good oral absorption (< 140 A²)
3
H-Bond Donors
9
H-Bond Acceptors
913
Complexity
SMILES
Canonical SMILES
SMILES: CCN1CCN(CC1)C2=CC(=C(C=C2)NC3=CC(=NC=N3)N(C)C(=O)NC4=C(C(=CC(=C4Cl)OC)OC)Cl)NC(=O)C=CIsomeric SMILES
SMILES: CCN1CCN(CC1)C2=CC(=C(C=C2)NC3=CC(=NC=N3)N(C)C(=O)NC4=C(C(=CC(=C4Cl)OC)OC)Cl)NC(=O)C=CSynonyms(20)
H3B-65271702259-66-24HTE364XIKH3b 6527H3B65272-Propenamide, N-(2-((6-((((2,6-dichloro-3,5-dimethoxyphenyl)amino)carbonyl)methylamino)-4-pyrimidinyl)amino)-5-(4-ethyl-1-piperazinyl)phenyl)-N-(2-((6-(((2,6-Dichloro-3,5 dimethoxyphenyl) carbamoyl) (methyl)amino)pyrimidin-4-yl)amino)-5-(4-ethylpiperazin-1-yl)phenyl)prop-2-enamideRefChem:144964FGFR4 INHIBITOR H3B-6527Fibroblast Growth Factor Receptor 4 Inhibitor H3B-6527N-(2-((6-(3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-methylureido)pyrimidin-4-yl)amino)-5-(4-ethylpiperazin-1-yl)phenyl)acrylamideN-[2-[[6-[(2,6-dichloro-3,5-dimethoxyphenyl)carbamoyl-methylamino]pyrimidin-4-yl]amino]-5-(4-ethylpiperazin-1-yl)phenyl]prop-2-enamideMFCD30377210N-[2-[[6-[3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-methylureido]-4-pyrimidinyl]amino]-5-(4-ethyl-1-piperazinyl)phenyl]acrylamideMBWRLLRCTIYXDW-UHFFFAOYSA-N
Data from PubChem (NCBI)
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