Molecular Identity
Hydrochlorothiazide
6-chloro-1,1-dioxo-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide
PubChem CID: 3639
Hydrochlorothiazide is a benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure. It has a role as a diuretic, an antihypertensive agent, a xenobiotic and an environmental contaminant. It is a sulfonamide, an organochlorine compound and a benzothiadiazine.
2D Structure
Properties
C7H8ClN3O4S2
Molecular Formula
297.70
Molecular Weight
g/mol
296.9645
Exact Mass
Da
-0.1
XLogP
Drug-like (Lipinski: < 5)
135
TPSA
Good oral absorption (< 140 A²)
3
H-Bond Donors
7
H-Bond Acceptors
494
Complexity
SMILES
Canonical SMILES
SMILES: C1NC2=CC(=C(C=C2S(=O)(=O)N1)S(=O)(=O)N)ClIsomeric SMILES
SMILES: C1NC2=CC(=C(C=C2S(=O)(=O)N1)S(=O)(=O)N)ClSynonyms(20)
hydrochlorothiazide58-93-5EsidrixHCTZHypothiazideVetidrexHidrotiazidaIdrotiazideMegadiurilServithiazidNewtolideOreticChlorosulthiadilAquariusEsidrex
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Hydrochlorothiazide
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