Poziotinib
1-[4-[4-(3,4-dichloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]oxypiperidin-1-yl]prop-2-en-1-one
Molecular Identity
Poziotinib
1-[4-[4-(3,4-dichloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]oxypiperidin-1-yl]prop-2-en-1-one
PubChem CID: 25127713
Poziotinib is a member of the class of quinazolines that is quinazoline substituted by (3,4-dichloro-2-fluorophenyl)amino, [1-(prop-2-enoyl)piperidin-4-yl]oxy, and methoxy groups at positions 4, 6, and 7, respectively. It is a potent and irreversible tyrosine kinase inhibitor targeting EGFR and HER2 with exon 20 insertion mutations. It has a role as an antineoplastic agent, an apoptosis inducer and an epidermal growth factor receptor antagonist. It is a member of acrylamides, a dichlorobenzene, an aromatic ether, a member of quinazolines, a diether, a N-acylpiperidine, a substituted aniline, a secondary amino compound and a member of monofluorobenzenes.
2D Structure
Properties
C23H21Cl2FN4O3
Molecular Formula
491.30
Molecular Weight
g/mol
490.0975
Exact Mass
Da
5.4
XLogP
Above Lipinski threshold
76.6
TPSA
Good oral absorption (< 140 A²)
1
H-Bond Donors
7
H-Bond Acceptors
684
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
Poziotinib1092364-38-9NOV120101NOV-1201011-(4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)piperidin-1-yl)prop-2-en-1-oneHM-781-36BNOV-1201poziotinibumOEI6OOU6IK1-[4-[4-(3,4-dichloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]oxypiperidin-1-yl]prop-2-en-1-oneHM 781-36BHM-781-36DTXSID801488531-[4-({4-[(3,4-DICHLORO-2-FLUOROPHENYL)AMINO]-7-METHOXYQUINAZOLIN-6-YL}OXY)PIPERIDIN-1-YL]PROP-2-EN-1-ONE1-(4-(4-(3,4-dichloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl)oxypiperidin-1-yl)prop-2-en-1-one
Data from PubChem (NCBI)
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Drug Network
Trials and conditions connected to Poziotinib
Loading drug network...